3131-03-1

Basic information

• Product Name: mikamycin B
• Synonyms: N-[(3-Hydroxy-2-pyridinyl)carbonyl]-L-threonyl-(2R)-2-aMinobutanoyl-L-prolyl-4-(diMethylaMino)-N-Methyl-L-phenylalanyl-(2S)-4-oxo-2-piperidinecarbonyl-(2S)-2-phenylglycine (6-13)-lactone;NSC 92554;PA 114B;PristinaMycin P 1;Ostreogrycin B, PristinaMycin IA, StreptograMin B, Syncothrecin B1, Synergistin B, VernaMycin Balpha, VirginiaMycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535;VirginiaMycin B;mikamycin B;N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-4-(dimethylamino)-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-)
• CAS NO: 3131-03-1
• Molecular Formula: C₄₅H₅₄N₈O₁₀
• Molecular Weight: 866.95786
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 3131-03-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 198°
• Boiling Point: 780.3°C (rough estimate)
• Flash Point: 680.8°C
• Appearance: /
• Density: 1.1881 (rough estimate)
• Refractive Index: 1.6910 (estimate)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain)
• CAS DataBase Reference: mikamycin B(CAS DataBase Reference)
• NIST Chemistry Reference: mikamycin B(3131-03-1)
• EPA Substance Registry System: mikamycin B(3131-03-1)

Safety Data

• RIDADR: 3172
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 3131-03-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 3131-03-1 differently. You can refer to the following data:
1. One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810).
2. Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Definition

ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis s including methicillin-resistant Staphylococcus aureus.

InChI:InChI=1/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)/t26?,31?,32?,33?,34-,36?,37?/m0/s1

Downstream Products

• 1121-25-1 2-methyl-3-pyridinol 
• 14047-53-1 3-hydroxy-2-hydroxymethylpyridine 
• 143381-36-6 (3S,6S,12R,15S,16R,19S,22S)-15-Amino-3-(4-dimethylamino-benzyl)-12-ethyl-4,16-dimethyl-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacosane-2,5,11,14,18,21,24-heptaone 
• 21625-41-2 C₄₆H₅₆N₈O₁₀ 
• 170745-13-8 C₄₇H₅₈N₈O₁₀ 
• 84873-18-7 3-Hydroxy-pyridine-2-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S,24R)-3-(4-dimethylamino-benzyl)-12-ethyl-24-hydroxy-4,16-dimethyl-2,5,11,14,18,21-hexaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl]-amide 
• 84873-18-7 3-Hydroxy-pyridine-2-carboxylic acid [(3S,6S,12R,15S,16R,19S,22S,24S)-3-(4-dimethylamino-benzyl)-12-ethyl-24-hydroxy-4,16-dimethyl-2,5,11,14,18,21-hexaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaaza-tricyclo[20.4.0.0^6,10]hexacos-15-yl]-amide