848735-65-9Relevant academic research and scientific papers
Synthesis of Isoxazolines and Isoxazoles via Metal-Free Desulfitative Cyclization
Cheng, Jiaxin,Yang, Ze,Li, Yuansheng,Xi, Yulan,Sun, Qiu,He, Ling
, p. 2385 - 2393 (2018)
A novel, one-pot reaction for the synthesis of isoxazolines and isoxazoles is developed via a cascade process under metal-free conditions. The approach involves the formation of intramolecular C-N and C-O bonds and intermolecular C-C bonds from aromatic alkenes or alkynes and N -hydroxysulfonamides using hypervalent iodine(VII) and iodine as the oxidant. Activation of C-H and C-C bonds/construction of C-O bonds/elimination of SO 2 /C-N bond formation is achieved in sequence in the reaction system.
Simple preparation method of isoxazoline
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Paragraph 0035, (2021/07/24)
The invention discloses a simple preparation method of isoxazoline. The simple preparation method is characterized in that a series of isoxazoline compounds are efficiently synthesized by using aldehyde, p-toluenesulfonhydrazide, olefin and tert-butyl nit
Expeditious preparation of isoxazoles from Δ2-isoxazolines as advanced intermediates for functional materials
Vilela, Guilherme D.,Da Rosa, Rafaela R.,Schneider, Paulo H.,Bechtold, Ivan H.,Eccher, Juliana,Merlo, Aloir A.
, p. 6569 - 6572 (2012/01/03)
A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction of aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO2-oxidation reaction furnished the title compounds which were purified by simple filtration on celite.
