31554-58-2Relevant academic research and scientific papers
O-iodoxy benzoic acid–mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids
Desai, Vidya G.,Naik, Sneha R.,Dhumaskar, Kashinath L.
, p. 1453 - 1460 (2016/09/23)
A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from a,b-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.
Synthesis of 3,5-diarylisoxazoles under solvent-free conditions using iodobenzene diacetate
Chandra Sekhar, Kondapalli Venkata Gowri,Sasank, Thripuraribhatla Venkata Naga Varuna Tara,Nagesh, Hunsur Nagendra,Suresh, Narva,Naidu, Kalaga Mahalakshmi,Suresh, Amaroju
, p. 1045 - 1048 (2014/01/06)
A simple and efficient method has been developed for conversion of chalcone oximes to 3,5-diaryl isoxazoles in excellent yields under solvent-free conditions. The synthesized compounds were characterized by infrared spectroscopy, 1H NMR, 13C NMR and HRMS.
Expeditious preparation of isoxazoles from Δ2-isoxazolines as advanced intermediates for functional materials
Vilela, Guilherme D.,Da Rosa, Rafaela R.,Schneider, Paulo H.,Bechtold, Ivan H.,Eccher, Juliana,Merlo, Aloir A.
, p. 6569 - 6572 (2012/01/03)
A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction of aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO2-oxidation reaction furnished the title compounds which were purified by simple filtration on celite.
