84877-44-1 Usage
Chemical class
Organic sulfonic acid esters
Formation reaction
Reaction of 2,2,2-trifluoro-1-(4-methylphenyl)ethanol with 4-methylbenzenesulfonyl chloride
Usage
Reagent in organic synthesis (formation of esters and other organic functional groups), intermediate in the production of active pharmaceutical ingredients
Physical properties
Colorless to pale yellow liquid, faint odor
Safety precautions
Potential irritant and allergic properties, handle with care
Check Digit Verification of cas no
The CAS Registry Mumber 84877-44-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,8,7 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84877-44:
(7*8)+(6*4)+(5*8)+(4*7)+(3*7)+(2*4)+(1*4)=181
181 % 10 = 1
So 84877-44-1 is a valid CAS Registry Number.
84877-44-1Relevant articles and documents
A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore
Pauff, Steven M.,Miller, Stephen C.
, p. 711 - 716 (2013/02/25)
Sulfonated molecules exhibit high water solubility, a property that is valuable for many biological applications but often complicates their synthesis and purification. Here we report a sulfonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroacetic acid (TFA). The use of this protecting group improved the synthesis of a sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product without requiring chromatography.
Substituent effects. XX. Highly electron-deficient carbocation solvolyses
Murata,Sakaguchi,Fujiyama,Mishima,Fujio,Tsuno
, p. 1138 - 1145 (2007/10/02)
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