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848819-60-3

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848819-60-3 Usage

General Description

1-BOC-2-(2'-chloroacetyl)-pyrrolidine is a chemical compound that is used in the synthesis of various pharmaceuticals and organic molecules. It is a derivative of pyrrolidine and contains a BOC (tert-butoxycarbonyl) protective group, as well as a chloroacetyl functional group. The BOC group provides protection for reactive sites on the molecule, allowing for selective reactions to occur at specific sites. The chloroacetyl group introduces reactivity and can be used to further modify the molecule through subsequent chemical reactions. 1-BOC-2-(2'-CHLOROACETYL)-PYRROLIDINE is commonly used as an intermediate in the synthesis of drugs, agrochemicals, and other organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 848819-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,8,1 and 9 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 848819-60:
(8*8)+(7*4)+(6*8)+(5*8)+(4*1)+(3*9)+(2*6)+(1*0)=223
223 % 10 = 3
So 848819-60-3 is a valid CAS Registry Number.

848819-60-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 2-(2-chloroacetyl)pyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names (R)-TERT-BUTYL 2-(2-CHLOROACETYL)PYRROLIDINE-1-CARBOXYLATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:848819-60-3 SDS

848819-60-3Downstream Products

848819-60-3Relevant articles and documents

PROTEIN SECRETION INHIBITORS

-

Paragraph 00205, (2022/03/09)

Provided herein are secretion inhibitors, such as inhibitors of Sec61 for example of Formula (I), methods for their preparation, related pharmaceutical compositions, and method for using the same.

Efficient and Scalable Synthesis of Glucokinase Activator with a Chiral Thiophenyl-Pyrrolidine Scaffold

Fujieda, Hiroki,Maeda, Koji,Kato, Noriyasu

, p. 69 - 77 (2019/01/24)

Herein we describe the practical synthesis of a potent glucokinase activator (1) that has a chiral thiophenyl-pyrrolidine scaffold. The key to the successful synthesis was the application of a telescoped chiral-pool synthesis from a commercially available l-proline methyl ester derivative to introduce the chirality of the thiophenyl-pyrrolidine moiety. This second-generation synthesis of 1 provided several advantages over the previous method including an operational simplicity and avoidance of purification by column chromatography. The industrial relevance of this synthetic method in large-scale preparation was demonstrated by the production of 54.6 kg of 1 with an excellent chemical and optical purity.

Continuous flow synthesis of α-halo ketones: Essential building blocks of antiretroviral agents

Pinho, Vagner D.,Gutmann, Bernhard,Miranda, Leandro S. M.,De Souza, Rodrigo O. M. A.,Kappe, C. Oliver

, p. 1555 - 1562 (2014/03/21)

The development of a continuous flow process for the multistep synthesis of α-halo ketones starting from N-protected amino acids is described. The obtained α-halo ketones are chiral building blocks for the synthesis of HIV protease inhibitors, such as atazanavir and darunavir. The synthesis starts with the formation of a mixed anhydride in a first tubular reactor. The anhydride is subsequently combined with anhydrous diazomethane in a tube-in-tube reactor. The tube-in-tube reactor consists of an inner tube, made from a gas-permeable, hydrophobic material, enclosed in a thick-walled, impermeable outer tube. Diazomethane is generated in the inner tube in an aqueous medium, and anhydrous diazomethane subsequently diffuses through the permeable membrane into the outer chamber. The α-diazo ketone is produced from the mixed anhydride and diazomethane in the outer chamber, and the resulting diazo ketone is finally converted to the halo ketone with anhydrous ethereal hydrogen halide. This method eliminates the need to store, transport, or handle diazomethane and produces α-halo ketone building blocks in a multistep system without racemization in excellent yields. A fully continuous process allowed the synthesis of 1.84 g of α-chloro ketone from the respective N-protected amino acid within ~4.5 h (87% yield).

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