848826-48-2Relevant academic research and scientific papers
Photochemical Amplifier Based on Self-Immolative Dendritic Spacers
Kastrati, Agonist,Bochet, Christian G.
, p. 7776 - 7785 (2019/06/27)
A self-immolative dendritic structure was synthesized. It is based on phenol derivatives with three hydroxymethyl arms at both ortho and para positions of the core unit, potentially releasing up to 27 leaving groups in a third-generation dendrimer. The tr
Single-triggered trimeric prodrugs
Haba, Keren,Popkov, Mikhail,Shamis, Marina,Lerner, Richard A.,Barbas, Carlos F.,Shabat, Doron
, p. 717 - 720 (2007/10/03)
The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve select
