848828-80-8Relevant academic research and scientific papers
Modular synthesis of cyclic peptidomimetics inspired by γ-turns
Ramanathan, Senthil Kumar,Keeler, John,Lee, Huey-Lih,Srinavasa Reddy,Lushington, Gerald,Aube, Jeffrey
, p. 1059 - 1062 (2007/10/03)
(Chemical Equation Presented) A series of peptidomimetics based on a γ-turn motif were synthesized using a modular approach, in which N-protected piperidones were reacted with a selection of 2-hydroxyalkyl azides derived from common L-amino acids. Hydrolysis of the initially formed iminium ethers afforded the targeted series of substituted 1,4-diazepin-5-ones.
