848841-50-9Relevant academic research and scientific papers
The synthesis of a novel inhibitor of B-Raf kinase
Denni-Dischert, Donatienne,Marterer, Wolfgang,Baenziger, Markus,Yusuff, Naeem,Batt, David,Ramsey, Tim,Geng, Peng,Michael, Walter,Wang, Run-Ming B.,Taplin Jr., Francis,Versace, Richard,Cesarz, David,Perez, Lawrence B.
, p. 70 - 77 (2012/12/21)
A scaleable synthetic route to [4,7′]bis-isoquinolinyl-1-yl-(2-tert- butyl-pyrimidine-5-yl)amine (1), an inhibitor of B-Raf kinase is described. The key step in the synthesis is the Pd-catalyzed Negishi coupling of 4-bromo-1-chloroisoquinoline with triflu
1,4-DISUBSTITUTED ISOQUINILONE DERIVATIVES AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
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Page/Page column 52-53, (2010/02/11)
This invention relates to compounds of formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.
