848847-22-3

Upstream product

• 56962-11-9 2-chloro-4-hydroxybenzaldehyde 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 919088-55-4 2-chloro-4-[3-(4-methyl-[1,4]diazepan-1-yl)-propoxy]-benzaldehyde 
• 848847-23-4 2-Chloro-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzaldehyde 

Relevant academic research and scientific papers

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor. Structure-activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H4 receptor.

Benzoimidazole compounds

Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.

Imidazole compounds

Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related con