84885-74-5Relevant academic research and scientific papers
Synthesis of (cis-6-Methyltetrahydropyran-2-yl)acetic Acid Involving the Use of an Organoselenium-mediated Cyclization Reaction
Ley, Steven V.,Lygo, Barry,Molines, Huguette,Morton, Judith A.
, p. 1251 - 1252 (1982)
A short stereospecific synthesis of (cis-6-methyltetrahydropyran-2-yl) acetic acid (1) has been achieved from readily available starting materials using a novel organoselenium-mediated cyclization of alkenyl-substituted β-oxoesters.
Synthesis of (+/-)-cis-6-Methyltetrahydropyran-2-ylacetic Acid, a Natural Product from Viverra civetta, using Organoselenium-mediated Cyclisation Reactions
Ley, Steven V.,Lygo, Barry,Molines, Huguette
, p. 2403 - 2406 (2007/10/02)
Two highly stereoselective syntheses of the natural product (+/-)-cis-6-methyltetrahydropyran-2-ylacetic acid (1) are described.The shorter of these is a three-step synthesis involving kinetic alkylation of the dianion derived from benzyl acetoacetate wit
