848850-76-0

Upstream product

• 111-42-2 2,2'-iminobis[ethanol] 
• 581095-20-7 (S)-2-Bromomethyl-1-[2-(diphenyl-phosphinoyl)-6-methoxy-phenyl]-pyrrolidine 
• 848850-67-9 (R)-3-Bromo-1-[2-(diphenyl-phosphinoyl)-6-methoxy-phenyl]-piperidine 
• 511553-39-2 (S)-1-[2'-(diphenylphosphinyl)-6'-methoxyphenyl]-2-(hydroxymethyl)pyrrolidine 

Downstream Products

• 581095-21-8 2-[[(S)-1-(2-Diphenylphosphanyl-6-methoxy-phenyl)-pyrrolidin-2-ylmethyl]-(2-hydroxy-ethyl)-amino]-ethanol 

Relevant academic research and scientific papers

Amination of N-aryl prolinol via ring expansion and contraction: Application to the chiral ligand for the catalytic asymmetric reaction

(Chemical Equation Presented) Chiral diaminophosphines 4 were prepared from (S)-prolinol-derived aminophosphine oxide 5 by bromination with ring expansion followed by animation with ring contraction and reduction, using trichlorosilane. In the presence of

Chiral diaminophosphine ligands with stable C(aryl)-N(amine) axial chirality derived from prolinol

New type chiral ligands 3, which have a chiral carbon center and stable C(aryl)-N(amine) axial chirality, were prepared from chiral prolinol-derived aminophosphine oxide 4. Pd-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (6)