848891-74-7Relevant articles and documents
A stereocontrolled route to protected isocyanates from alcohols
Cane-Honeysett, Daniel J.,Dowle, Michael D.,Wood, Mark E.
, p. 2141 - 2148 (2005)
Full details are given for a modified Mitsunobu approach to the formation of N-alkylated 1,2,4-dithiazolidine-3,5-diones 2 from a wide range of alcohols 10 with predominantly, inversion of configuration. The resulting products 2 can be regarded as protected isocyanates 6.
1,2,4-Dithiazolidine-3,5-dione as an isocyanate equivalent in the Mitsunobu reaction
Wood, Mark E.,Cane-Honeysett, Daniel J.,Dowle, Michael D.
, p. 2046 - 2047 (2007/10/03)
1,2,4-Dithiazolidine-3,5-dione 1 can be used as a nitrogen nucleophile in a modified Mitsunobu procedure to give N-alkylated products 2 which can be converted via isocyanates, into amine derivatives, under very mild conditions.