147253-97-2

Basic information

• Product Name: Carbamic acid, [(1S)-1-phenylethyl]-, phenylmethyl ester
• CAS NO: 147253-97-2
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol File: 147253-97-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-phenylethyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-phenylethyl]-, phenylmethyl ester(147253-97-2)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-phenylethyl]-, phenylmethyl ester(147253-97-2)

Safety Data

• Hazardous Substances Data: 147253-97-2(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 1445-91-6 (S)-1-phenylethanol 
• 3459-92-5 DBC 
• 618-36-0 rac-methylbenzylamine 
• 1517-69-7 (R)-1-phenylethanol 
• 100-51-6 benzyl alcohol 
• 848891-74-7 (S)-4-(1-phenylethyl)-1,2,4-dithiazolidine-3,5-dione 
• 63436-83-9 benzyl isopropenyl carbonate 

Downstream Products

• 147169-48-0 (S)-tert-butyl 1-phenylethylcarbamate 
• 14185-42-3 (S)-methyl (1-phenylethyl)carbamate 
• 19035-02-0 (S)-N-phenyl-N'-(1-phenylethyl)urea 

Relevant articles and documents

Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: Total synthesis of (+)-Sertraline

The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described (Figure presented).

A stereocontrolled route to protected isocyanates from alcohols

Full details are given for a modified Mitsunobu approach to the formation of N-alkylated 1,2,4-dithiazolidine-3,5-diones 2 from a wide range of alcohols 10 with predominantly, inversion of configuration. The resulting products 2 can be regarded as protected isocyanates 6.