848927-67-3

Upstream product

• 848927-70-8 (3S)-3-(benzyloxy)-N-hydroxypiperidine 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 848927-69-5 (2S)-2-(benzyloxy)-1,5-bis(para-toluenesulfonyloxy)pentane 
• 848927-68-4 dimethyl (2S)-2-(benzyloxy)pentanedioate 
• 55094-97-8 (S)-dimethyl 2-hydroxypentanedioate 

Downstream Products

• 24159-07-7 febrifugine 
• 848927-72-0 (2R,3S)-N-(tert-butoxycarbonyl)-3-(benzyloxy)-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidine 
• 1171136-66-5 (2R,3aR,4S)-2-phenyl-4-(benzyloxy)-hexahydroisoxazolo[2,3-a]pyridine 
• 1171136-68-7 (2S,3aS,4S)-2-phenyl-4-(benzyloxy)-hexahydroisoxazolo[2,3-a]pyridine 
• 1171136-80-3 (2R,3aR,4S)-4-(benzyloxy)-2-[(4-oxo-4H-quinazolin-3-yl)methyl]hexahydroisoxazolo[2,3-a]pyridine 
• 1171136-81-4 (2S,3aS,4S)-4-(benzyloxy)-2-[(4-oxo-4H-quinazolin-3-yl)methyl]hexahydroisoxazolo[2,3-a]pyridine 
• 1171137-00-0 (2S,3aR,4S)-4-(benzyloxy)-2-methyl-2-(trimethylsilyloxy)-hexahydro-2H-isoxazolo[2,3-a]pyridine 
• 1171136-99-4 (2R,3aR,4S)-4-(benzyloxy)-2-methyl-2-(trimethylsilyloxy)-hexahydro-2H-isoxazolo[2,3-a]pyridine 
• 1171137-03-3 (2R,3aS,4S)-4-(benzyloxy)-2-methyl-2-(trimethylsilyloxy)-hexahydro-2H-isoxazolo[2,3-a]pyridine 
• 1171137-16-8 (2R,3aR,4S)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-4-(benzyloxy)hexahydroisoxazolo[2,3-a]pyridine 
• 1171137-19-1 (2S,3aS,4S)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-4-(benzyloxy)hexahydroisoxazolo[2,3-a]pyridine 
• 1171137-14-6 (2R,3aR,4S)-2-hydroxymethyl-4-(benzyloxy)-hexahydroisoxazolo[2,3-a]pyridine 
• 1171137-11-3 (2S,3aR,4S)-2-hydroxymethyl-4-(benzyloxy)-hexahydroisoxazolo[2,3-a]pyridine 
• 1171137-15-7 (2S,3aS,4S)-2-hydroxymethyl-4-(benzyloxy)-hexahydroisoxazolo[2,3-a]pyridine 

Relevant academic research and scientific papers

Synthetic evaluation of an enantiopure tetrahydropyridine N-oxide. Synthesis of (+)-febrifugine

A study into the synthesis and synthetic utility of (S)-3-benzyloxy-3,4,5,6-tetrahydropyridine N-oxide is described. This nitrone is readily accessed from l-glutamic acid and the regio- and stereoselectivity of cycloaddition of this compound with a range

A convergent enantioselective synthesis of the anti-malarial agent (+)-febrifugine

Chiral pool derived 3-benzyloxy-3,4,5,6-tetrahydropyridine N-oxide underwent regio- and diastereoselective 1,3-dipolar cycloaddition with N-allylquinazolone to give a cycloadduct that was elaborated to (+)-febrifugine a potent anti-malarial alkaloid.