848937-70-2

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 104-94-9 4-methoxy-aniline 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 

Downstream Products

• 1018833-05-0 N-[4-(6-chloro-3-pyridinyl)phenyl]-N'-[4-(methyloxy)phenyl]sulfamide 
• 1018833-06-1 N-[4-(6-chloro-3-pyridinyl)phenyl]-N'-[4-(4-pyridinyloxy)phenyl]sulfamide 
• 1245920-59-5 C₁₈H₂₂N₂O₃S 
• 1613330-73-6 (±)-2-allyl-N-(4-methoxyphenyl)pyrrolidine-1-sulfonamide 
• 1613330-74-7 (±)-(2S*,5R*)-2,5-diallyl-N-(4-methoxyphenyl)pyrrolidine-1-sulfonamide 
• 1613330-97-4 (±)-2-allyl-N-(4-methoxyphenyl)piperidine-1-sulfonamide 

Relevant academic research and scientific papers

Synthesis, crystal structure and antibacterial evaluation of substituted perhydro-1, 3-oxazin-2-ones containing N-phenylsulfonamide

The synthesis of a new series of TV-substituted perhydro-1,3-oxazin-2-ones containing V-phenylsulfonamide is described. The compounds 7a-7f were obtained in a one-pot reaction from chlorosulfonyl isocyanate, selected 1, 3-halogenoalcohols and various aromatic amines in alkaline conditions, to give the target N-heterocyclic 6-membered ring compounds with good yields. The X-ray crystal structure of N-[(N-4-fluorophenyl)sulfamoyl]perhydro-1, 3-oxazin-2-one 7d was solved. All the synthesized compounds have been screened for their invitro antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Structures of 7d and 6e can be further optimized to give new potent antibacterial agents with structures significantly different from those of existing classes of antibiotics. The Japan Institute of Heterocyclic Chemistry.

Modular synthesis of 1,2-Diamine derivatives by palladium-Catalyzed aerobic oxidative cyclization of allylic sulfamides

Chemical equation presented Allylic sulfamides undergo aerobic oxidative cyclization at room temperature, mediated by a Pd(O 2CCF3)2/DMSO catalyst system in tetrahydrofuran. The cyclic sulfamide products are readily converted into 1,2-diamines, and substrates derived from chiral allylic amines cyclize with very high diastereoselectivity.

MODULATORS OF MULTIPLE KINASES

Compound structures are provided which should modulate various selected kinases thereby regulating the corresponding kinase signal pathways. These pathways have been shown to regulate biological functions. The compounds, and similar variants, will be useful in therapeutic or diagnostic methods related to said kinases. In particular, improved effects on functional pathways mediated by kinases can be achieved by modulating selected combinations of kinases.