848952-83-0

Basic information

• Product Name: 5-Chloropyrazine-2-carboxylic acid hydrazide
• Synonyms: 5-Chloropyrazine-2-carboxylic acid hydrazide;5-chloropyrazine-2-carbohydrazide;5-chloropyrazine-2-carboxylic acid hydyazide
• CAS NO: 848952-83-0
• Molecular Formula: C₅H₅ClN₄O
• Molecular Weight: 172.574
• EINECS: 1312995-182-4
• Mol File: 848952-83-0.mol

Chemical Properties

• Appearance: /
• Density: 1.496g/cm³
• Refractive Index: 1.607
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.51±0.10(Predicted)
• CAS DataBase Reference: 5-Chloropyrazine-2-carboxylic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloropyrazine-2-carboxylic acid hydrazide(848952-83-0)
• EPA Substance Registry System: 5-Chloropyrazine-2-carboxylic acid hydrazide(848952-83-0)

Safety Data

• Hazardous Substances Data: 848952-83-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloropyrazine-2-carboxylic acid hydrazide is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agricultural Industry:
5-Chloropyrazine-2-carboxylic acid hydrazide is used as a potential precursor for the synthesis of bioactive compounds with pesticidal or herbicidal properties. Its structural similarity to known agricultural chemicals suggests that it may have potential as a pesticide or herbicide, offering new options for crop protection and management.

InChI:InChI=1/C5H5ClN4O/c6-4-2-8-3(1-9-4)5(11)10-7/h1-2H,7H2,(H,10,11)

Upstream product

• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 
• 54013-04-6 ethyl 5-chloro-2-pyrazinecarboxylate 
• 36070-80-1 5-chloropyrazinoic acid 
• 1254073-53-4 1,1-dimethylethyl 2-[(5-chloro-2-pyrazinyl)carbonyl]hydrazinecarboxylate 

Downstream Products

• 848952-92-1 2-chloro-5-(5-methyl-[1,3,4]oxadiazol-2-yl)-pyrazine 

Relevant articles and documents

Synthesis and anticancer activity of new hydrazide-hydrazones and their Pd(II) complexes

Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising –CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: 5-Chloro-N’-[(substituted)methylidene] p

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A series of 6-hetaryloxy benzoxaborole compounds was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the changes in antimalarial activity which result from 6-aryloxy structural variation, substituent modification on the pyrazine ring, and optimization of the side chain ester group. This SAR study discovered highly potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles (9, 27-34) with IC50s = 0.2-22 nM against cultured Plasmodium falciparum W2 and 3D7 strains. Compound 9 also demonstrated excellent in vivo efficacy against P. berghei in infected mice (ED90 = 7.0 mg/kg).

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The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

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