849034-07-7

Upstream product

• 83036-57-1 (E)-1-(3,7-dimethylocta-2,6-dien-1-yl)-2,3,4,5-tetramethoxy-6-methylbenzene 
• 35896-58-3 2,3,4,5-tetramethoxytoluene 
• 5677-55-4 ubiquinone Q₂ 
• 203059-93-2 4a-((E)-3,7-Dimethyl-octa-2,6-dienyl)-6,7-dimethoxy-8a-methyl-1,4,4a,8a-tetrahydro-1,4-methano-naphthalene-5,8-dione 
• 152984-32-2 4,5-dimethoxy-2-methyltricyclo[6.2.1.0^2,7]undeca-4,9-diene-3,6-dione 
• 606-06-4 2-[(E)-3,7-dimethyl-2,6-octadienyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone 
• 6138-90-5 trans-geranyl bromide 
• 73875-27-1 2,3,4,5-tetramethoxy-6-methyl-1-bromobenzene 
• 3066-90-8 2,3-dimethoxy-5-methylbenzene-1,4-diol 
• 605-94-7 2,3-Dimethoxy-5-methyl-1,4-benzoquinone 

Downstream Products

• 99348-11-5 4-methyl-6-(2-methyl-3,4,5,6-tetramethoxyphenyl)hex-4-enoic acid 
• 85216-20-2 4-methyl-6-(2-methyl-3,4,5,6-tetramethoxyphenyl)hex-4-en-1-ol 
• 26539-07-1 4-methyl-6-(3-methyl-5,6-dimethoxy-1,4-benzoquinon-2-yl)hex-4-enoic acid 
• 85228-79-1 1-<(2E)-6,7-epoxy-3,7-dimethyloct-2-enyl>-2,3,4,5-tetramethoxy-6-methylbenzene 

Relevant academic research and scientific papers

The preparation of side chain functionalized analogues of coenzyme Q for protein conjugation studies

The synthesis of two analogues of CoQ (10 and 13) suitable for conjugation to a peptide or protein, and hence the development of an ELISA immunoassay, is presented. These analogues were synthesized from the protected quinone, 1-bromo-2-methyl-3,4,5,6-tetramethoxybenzene (1), itself prepared from commercially available CoQ-0 (3). Model coupling studies of one of the analogues (10) to N-acetyl-L-lysine methyl ester and a lysine containing dipeptide (N-acetylglycine-L-lysine methyl ester) were also undertaken as a first step to monoclonial antibody production.