849050-70-0

Basic information

• Product Name: Sulfamide, N-methyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-N'-[2-[3-pyrazinyl-5-(2- thienyl)-1H-pyrazol-4-yl]ethyl]-
• CAS NO: 849050-70-0
• Molecular Formula: C25H29N7O2S2
• Molecular Weight: 523.683
• Mol File: 849050-70-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Sulfamide, N-methyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-N'-[2-[3-pyrazinyl-5-(2- thienyl)-1H-pyrazol-4-yl]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Sulfamide, N-methyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-N'-[2-[3-pyrazinyl-5-(2- thienyl)-1H-pyrazol-4-yl]ethyl]-(849050-70-0)
• EPA Substance Registry System: Sulfamide, N-methyl-N-[(3R)-1-(phenylmethyl)-3-pyrrolidinyl]-N'-[2-[3-pyrazinyl-5-(2- thienyl)-1H-pyrazol-4-yl]ethyl]-(849050-70-0)

Safety Data

• Hazardous Substances Data: 849050-70-0(Hazardous Substances Data)

Upstream product

• 1323996-20-8 C₂₁H₁₅N₃O₄S 
• 849052-09-1 4-Azido-1-thiophen-2-yl-butan-1-one 
• 849052-10-4 2-(2-Azido-ethyl)-1-pyrazin-2-yl-3-thiophen-2-yl-propane-1,3-dione 
• 849052-11-5 2-[4-(2-Azido-ethyl)-5-thiophen-2-yl-2H-pyrazol-3-yl]-pyrazine 
• 849052-12-6 2-(5-Pyrazin-2-yl-3-thiophen-2-yl-1H-pyrazol-4-yl)-ethylamine 
• 14145-87-0 2-(4-Oxo-4-thiophen-2-yl-butyl)-isoindole-1,3-dione 
• 43076-59-1 4-chloro-1-(thien-2-yl)-1-butanone 

Relevant articles and documents

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase

A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.