43076-59-1

Basic information

• Product Name: GAMMA-CHLORO-2-BUTYROTHIENONE
• Synonyms: 4-CHLORO-1-(2-THIENYL)BUTANONE;4-CHLORO-2'-BUTYROTHIENONE;4-CHLOROBUTYROTHIENONE;4-chloro-1-(2-thienyl)butan-1-one;gamma-Chloro-2-butyrothienone,96%;3-Chloropropyl 2-thienyl tetone;γ-chloro-2-butyrothienone;4-Chloro-1-(2-thienyl)butanone, HPLC 97%
• CAS NO: 43076-59-1
• Molecular Formula: C₈H₉ClOS
• Molecular Weight: 188.67
• EINECS: 256-076-2
• Mol File: 43076-59-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 144-146°C 9mm
• Flash Point: >230 °F
• Appearance: clear gold to dark coloured liquid
• Density: 1.663 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.565(lit.)
• Storage Temp.: 0-6°C
• BRN: 508882
• CAS DataBase Reference: GAMMA-CHLORO-2-BUTYROTHIENONE(CAS DataBase Reference)
• NIST Chemistry Reference: GAMMA-CHLORO-2-BUTYROTHIENONE(43076-59-1)
• EPA Substance Registry System: GAMMA-CHLORO-2-BUTYROTHIENONE(43076-59-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 43076-59-1(Hazardous Substances Data)

Usage

Chemical Properties

clear gold to dark coloured liquid

Upstream product

• 5713-61-1 thiophen-2-yl magnesium bromide 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 64214-66-0 N-Methyl-N-methoxy-4-chlorobutanamide 
• 188290-36-0 thiophene 

Downstream Products

• 6193-47-1 cyclopropyl(2-thienyl)methanone 
• 121767-69-9 2-(3-bromo-2-thienyl)-2-(2-thienyl)tetrahydrofuran 
• 141809-41-8 4-[(2-Hydroxy-ethyl)-methyl-amino]-1-thiophen-2-yl-butan-1-one 
• 80087-46-3 1-Methyl-5-[3-(2-thenoyl)propyl]thio-1,2,3,4-tetrazole 
• 849050-70-0 C₂₅H₂₉N₇O₂S₂ 
• 1323995-82-9 C₁₅H₁₃N₃O₂S 
• 1323995-84-1 C₁₆H₁₅N₃O₃S 
• 1323995-93-2 C₁₅H₁₃N₅S 
• 1323995-95-4 C₁₆H₁₅N₅OS 
• 1323996-03-7 C₁₅H₁₅N₃S 
• 1323996-16-2 C₂₃H₁₇NO₄S 
• 1323996-18-4 C₂₄H₁₉NO₅S 
• 1352950-06-1 tert-butyl 3-((4-oxo-8-(4-oxo-4-(thiophen-2-yl)butyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate 

Relevant articles and documents

Synthesis of nitrogenated heterocycles by asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines

Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl) haloimines followed by treatment with a base to promote an intramolecular nucleophilic substitution process. N-Protected aziridines, pyrrolidines, piperidines, and azepanes bearing aromatic, heteroaromatic, and aliphatic substituents have been obtained in very high yields and diastereomeric ratios up to >99:1. The free heterocycles can be easily obtained by a simple and mild desulfinylation procedure. Both enantiomers of the free heterocycles can be prepared with the same good results by changing the absolute configuration of the sulfur atom of the sulfinyl group.

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase

A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.

MODERN FRIEDEL-CRAFTS CHEMISTRY XVI. REACTION OF THIOPHENE WITH BIFUNCTIONAL MOLECULES UNDER DIFFERENT FRIEDEL-CRAFTS CATALYSTS: ATTEMPTED SYNTHESIS OF CYCLOPENTA THIOPHENES AND DIHYDROBENZO THIOPHENES

The reaction of thiophene (1) with 3-chloropropionyl chloride (2), 4-chlorobutyryl chloride (3), crotonyl chloride (4) and cinnamoyl chloride (5) under different Friedel-Crafts catalysts (AlCl3/CH3NO2, FeCl3, and AlCl3/CS2) was investigated.The cyclic products 4,5-dihydro-6H-4-methylcyclopenta-thiophen-6-one, 5,6-dihydrobenzothiophen-7(4H)one and 4-phenyl-6H-cyclopentathiophen-6-one were formed.The different behaviors of compounds (2-5) towards thiophene were discussed.