849067-90-9

Usage

Uses

Used in Pharmaceutical Industry:
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE is used as an intermediate in the synthesis of various pharmaceuticals for its potential in anti-cancer and anti-inflammatory treatments. Its unique structure and functional group contribute to the development of new drugs with improved therapeutic effects.
Used in Material Chemistry:
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE is used as a building block in the synthesis of organic compounds and polymers, enabling the creation of novel materials with specific properties for various applications in material chemistry.
Used in Medicinal Chemistry Research:
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE is used as a research compound to study its biological activities and explore its potential in the development of new therapeutic agents. Its unique structure and functional group provide opportunities for further modification and optimization to enhance its pharmacological properties.

InChI:InChI=1/C8H6N2O/c11-5-6-3-7-1-2-9-8(7)10-4-6/h1-5H,(H,9,10)

Upstream product

• 149-73-5 trimethyl orthoformate 
• 849067-97-6 (1H-pyrrolo[2,3-b]pyridin-5-yl)methanol 
• 107-31-3 Methyl formate 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 849067-91-0 dimethyl-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-amine 
• 1196079-52-3 1-(4-methylphenyl)-1H-pyrrolo[2,3-b]pyridine 
• 1373516-14-3 1-p-tolyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 
• 1445856-01-8 1-tosyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 
• 1445856-02-9 1-tosyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde oxime 
• 1445856-00-7 (1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanamine 
• 849067-97-6 (1H-pyrrolo[2,3-b]pyridin-5-yl)methanol 
• 1357586-18-5 C₁₅H₁₄N₄O₂S 
• 900514-07-0 3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 

Relevant academic research and scientific papers

DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES

The present invention relates to the compound of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof. The present invention is further concerned with the use of such a compound or salt, stereoisomer, tautomer or N-oxide thereof as medicament and a pharmaceutical composition comprising said compound.

MAP4K4 (HGK) Inhibitors

The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.

2, 4-DIAMINE-PYRIMIDINE DERIVATIVE AS SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein A, Rla, Rlb, R2, R3, R4, R5, R6, R7, Rs, Ra, Rb, X1, X2, X3 and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders

HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS

Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.