84907-66-4Relevant academic research and scientific papers
Fast and Efficient Continuous Flow Method for the Synthesis of Ynones and Pyrazoles
Kandasamy, Mohanraj,Ganesan, Balaji,Hung, Min-Yuan,Lin, Wei-Yu
, p. 3183 - 3189 (2019)
In this study, we developed a convenient and efficient two-step method for the synthesis of ynones in a flow reactor, through the generation of lithium acetylide and its subsequent reactions with acid chlorides. Using this approach, we obtained the ynones in moderate to good yields at room temperature. Moreover, we transformed the ynones into pyrazole derivatives through coupling with hydrazines. This transition metal-free process, mild reaction conditions, and broad functional group tolerance are all attractive features in comparison with conventional bench-top methods.
Indium-mediated formation of propargyl ketones from aldehydes or acyl chlorides
Augé, Jacques,Lubin-Germain, Nadège,Seghrouchni, Latifa
, p. 819 - 821 (2007/10/03)
Propargyl ketones were prepared from aldehydes via an indium-mediated alkynylation reaction followed by an indium-mediated Oppenauer oxidation. They were also obtained via an indium-mediated alkynylation of the relevant acyl chlorides.
A NOVEL METHOD FOR THE SYNTHESIS OF ALKYNYL KETONES - A REACTION OF ALKYNYL BORANES WITH AMIDES
Yamaguchi, Masahiko,Waseda, Toshie,Hirao, Ichiro
, p. 35 - 36 (2007/10/02)
Alkynyl ketones are synthesized in high yields by the reaction of alkynyl boranes and amides under a mild reaction condition.
