849106-37-2

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[[(4-chlorophenyl)methyl]amino]-, 1,1-dimethylethyl ester
• CAS NO: 849106-37-2
• Molecular Formula: C17H25ClN2O2
• Molecular Weight: 324.851
• Mol File: 849106-37-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[[(4-chlorophenyl)methyl]amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[[(4-chlorophenyl)methyl]amino]-, 1,1-dimethylethyl ester(849106-37-2)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[[(4-chlorophenyl)methyl]amino]-, 1,1-dimethylethyl ester(849106-37-2)

Safety Data

• Hazardous Substances Data: 849106-37-2(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 622-95-7 4-chlorobenzyl bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 104-86-9 4-chlorobenzylamine 

Downstream Products

• 849106-38-3 (4-chloro-benzyl)-ethyl-piperidin-4-yl-amine 
• 849106-46-3 [(4-chloro-benzyl)-piperidin-4-yl-amino]-acetic acid methyl ester 

Relevant articles and documents

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins

The present invention is related to benzsulfonamide derivatives of formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzsulfonamide derivatives. Said benzsulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel benzsulfonamide derivatives as well as to methods of their preparation. The compounds of formula I according to the present invention being suitable pharmaceutical agents are those whereinAr1 is a substituted or unsubstituted aryl or heteroaryl group;Ar2 is a substituted or unsubstituted phenyl group;X is O or S, preferably O;R1 is hydrogen or a C1-C6-alkyl group, or R1 forms a substituted or unsubstituted 5-6-membered saturated or unsaturated ring with Ar1;n is an integer from 0 to 5, preferably between 1-3 and most preferred 1;Y within formula I is an unsubstituted or a substituted 4-12-membered saturated cyclic or bicyclic alkyl containing at least one nitrogen atom, whereby one nitrogen atom within said ring is forming a bond with the sulfonyl group of formula I thus providing a benzsulfonamide.