849112-00-1

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(3-hydroxypropyl)-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (2R,3S)-
• CAS NO: 849112-00-1
• Molecular Formula: C20H30N2O5
• Molecular Weight: 378.469
• Mol File: 849112-00-1.mol

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(3-hydroxypropyl)-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (2R,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(3-hydroxypropyl)-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (2R,3S)-(849112-00-1)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(3-hydroxypropyl)-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (2R,3S)-(849112-00-1)

Safety Data

• Hazardous Substances Data: 849112-00-1(Hazardous Substances Data)

Upstream product

• 849111-98-4 tert-butyl (S)-(3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)carboxylate 
• 849111-97-3 3-benzyloxycarbonylamino-2-phenylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 849111-99-5 3-benzyloxycarbonylamino-2-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 849112-11-4 (2R,3S)-2-Allyl-3-benzyloxycarbonylamino-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 112513-33-4 (1S,8R)-(+)-absouline 
• 849112-02-3 (1S,7aR)-(Hexahydro-pyrrolizin-1-yl)-carbamic acid benzyl ester 
• 849112-01-2 (2R,3S)-3-Benzyloxycarbonylamino-2-(3-methanesulfonyloxy-propyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A flexible carbanionic approach to protected trans-(2R,3S)-2-substituted 3-aminopyrrolidines: Application to the asymmetric synthesis of (+)-absouline

Based on the use of phenyl thioether (3S)-7 as a synthetic equivalent to the N- and α-dianions (3S)-2a, a new carbanionic approach to trans-(2R,3S)-2-substituted 3-aminopyrrolidines (10) is described. Application of the method to the asymmetric synthesis