849139-56-6Relevant articles and documents
Photoredox-mediated mono- And difluorination of remote unactivated methylene C(sp3)-H bonds of N-alkyl sulfonamides
Deng, Zhiqiang,Zhao, Zhenxiang,He, Gang,Chen, Gong
supporting information, p. 3631 - 3635 (2021/05/31)
A photoredox-mediated δ-C(sp3)-H fluorination of sulfonyl-protected primary alkylamines with Selectfluor is developed. The reaction can proceed in excellent monofluorination selectivity for amine substrates without α substituent. For α-substituted substrates, a slightly modified reaction conditions with two rounds of operation gives the δ,δ-difluorination products in good yield. Mechanistic studies suggest SET oxidation of sulfonamide group directly generates the key sulfonamide N radical intermediate, which triggers a 1,5-HAT process to form the δ alkyl radical.
Design and synthesis of procollagen C-proteinase inhibitors
Turtle, Eric,Chow, Nicholas,Yang, Charles,Sosa, Sergio,Bauer, Udo,Brenner, Mitch,Solow-Cordero, David,Ho, Wen-Bin
, p. 7397 - 7401 (2013/02/22)
Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds
