849203-60-7

Usage

Uses

Used in Pharmaceutical Industry:
1-Oxo-7-Boc-7-azaspiro[3.4]-octan-7-yl pentanedioate is used as a synthetic intermediate for the production of pharmaceuticals. Its unique spirocyclic structure and Boc-protected amine group enable the development of biologically active molecules with specific therapeutic properties. 1-Oxo-7-Boc-7-azaspiro[3....'s versatility in organic synthesis allows for the creation of a wide range of pharmaceutical agents.
Used in Agrochemical Industry:
In the agrochemical industry, 1-Oxo-7-Boc-7-azaspiro[3.4]-octan-7-yl pentanedioate is utilized as a synthetic intermediate for the development of agrochemicals. 1-Oxo-7-Boc-7-azaspiro[3....'s spirocyclic structure can confer specific biological activities, making it a valuable component in the synthesis of pesticides, herbicides, and other agrochemicals designed to protect crops and enhance agricultural productivity.
Overall, 1-Oxo-7-Boc-7-azaspiro[3.4]-octan-7-yl pentanedioate is a versatile and valuable compound in both the pharmaceutical and agrochemical industries, serving as a key building block for the synthesis of biologically active molecules with diverse applications.

Upstream product

• 849203-59-4 tert-butyl 10-oxa-7-azadispiro[2.0.5.1]decane-7-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 116808-70-9 cyclopropyldiphenylsulfonium triflate 
• 33462-81-6 cyclopropyldiphenylsulfonium tetrafluoroborate 

Downstream Products

• 1338247-76-9 1-hydroxy-7-azaspiro[1-3]nonan-7-tert-butyl carboxylate 
• 1100748-83-1 tert-butyl 1-(benzylamino)-7-azaspiro[3.5 ]nonane-7-carboxylate 

Relevant academic research and scientific papers

Oxidative Ring Expansion of Cyclobutanols: Access to Functionalized 1,2-Dioxanes

Cyclobutanols undergo an oxidative ring expansion with Co(acac)2 and triplet oxygen to give 1,2-dioxanols. The formation of an alkoxy radical drives the regioselective cleavage of the ring on the more substituted side before insertion of molecular oxygen. The reaction is particularly effective on secondary cyclobutanols but works also on certain tertiary alcohols. Further substitution with neutral nucleophiles under catalytic Lewis acid conditions led to original 1,2-dioxanes with a preferred 3,6-cis-configuration.

ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE

Substituted aryl and heteroaryl ether compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R 1, R 2, R 3, L, R 4, L 1, Q, and R 5 are as defined herein. These compounds and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES

The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key ion channels to control cell excitability, and abnormal neuronal activity particularly involved in the development and maintenance of persistent or chronic pain, and / or neurological disorders. These novel compounds are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which these ion channels are involved. The invention is also directed towards pharmaceutical formulations comprising these compounds and the uses of these compounds.

Use of cyclopropyl diphenylsulfonium trifluoromethanesulfonate as sulfur ylide reagent and method for preparation of four-membered cyclic ketone

The invention provides a use of cyclopropyl diphenylsulfonium trifluoromethanesulfonate as a sulfur ylide reagent and a method for preparation of four-membered cyclic ketone. The cyclopropyl diphenylsulfonium trifluoromethanesulfonate solves the problem that cyclopropyl diphenylsulfonium tetrafluoroborate as the traditional sulfur ylide reagent used in the synthesis of a four-membered cyclic ketone compound from aldehydes or ketones has large synthesis difficulty, complex operation and an expensive price. Under the same reaction conditions, the reactivity of cyclopropyl diphenylsulfonium trifluoromethanesulfonate is comparable to that of cyclopropyl diphenylsulfonium tetrafluoroborate and thus the cyclopropyl diphenylsulfonium trifluoromethanesulfonate can replace cyclopropyl diphenylsulfonium tetrafluoroborate and be used as a novel sulfur ylide reagent.

Synthesis of four novel natural product inspired scaffolds for drug discovery

Inspired by the novel spiro structures of a number of bioactive natural products such as the histrionicotoxins, a series of novel spiro scaffolds have been designed and robust syntheses developed. The scaffolds are ready-to-use building blocks and can be easily prepared on a 5-20 g scale. They contain two amino groups (one Boc-protected) and have been designed for ease of conversion to a lead generation library, using either amide formation or reductive amination procedures. The synthesis of the 1,9-diazaspiro[5.5]undecane and 3,7-diazaspiro[5.6]dodecane ring systems was achieved using RCM as the key step. A simple workup procedure is reported for the removal of highly colored ruthenium residues. The synthesis of the 1,8-diazaspiro[4.5]decane scaffold has been achieved using a bromine-mediated 5-endo cyclization of the corresponding 4-aminobutene intermediate under acidic conditions. This is the first example of this type of cyclization to be reported. A novel mechanism involving a bromine transfer reaction from an initially formed bromonium ion to a neighboring nitrogen atom is suggested as the reason for the failure of this type of reaction under "normal" bromination conditions. An unusual rearrangement of a 1-acyl-1,9-diazaspiro[5.5]undecane to the corresponding 9-acyl-1,9-diazaspiro[5.5]undecane is reported.

Cyclopentyl modulators of chemokine receptor activity

Cyclopentyl compounds of Formula (I) are modulators of chemokine receptor activity: wherein D, G, R2, R3 and R8 in Formula (I) are defined herein. The compounds, and pharmaceutically acceptable salts and individual diastereomers thereof, are useful in the treatment and prevention of HIV infection, in delaying the onset of AIDS, and in the treatment of AIDS. The compounds are also useful for treating other diseases and conditions mediated by chemokine receptors.