849218-30-0

Basic information

• Product Name: 1,1-Cyclopropanedicarboxamide, N-[3-(aminomethyl)phenyl]-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl ]-, mono(trifluoroacetate)
• CAS NO: 849218-30-0
• Molecular Formula: C29H28N4O5.C2HF3O2
• Molecular Weight: 626.589
• Mol File: 849218-30-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-Cyclopropanedicarboxamide, N-[3-(aminomethyl)phenyl]-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl ]-, mono(trifluoroacetate)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Cyclopropanedicarboxamide, N-[3-(aminomethyl)phenyl]-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl ]-, mono(trifluoroacetate)(849218-30-0)
• EPA Substance Registry System: 1,1-Cyclopropanedicarboxamide, N-[3-(aminomethyl)phenyl]-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl ]-, mono(trifluoroacetate)(849218-30-0)

Safety Data

• Hazardous Substances Data: 849218-30-0(Hazardous Substances Data)

Upstream product

• 7409-30-5 p-nitrobenzylamine 
• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 849217-77-2 1-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamoyl)cyclopropane-1-carboxylic acid 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 
• 849218-31-1 [4-({1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarbonyl}-amino)-benzyl]-carbamic acid tert-butyl ester 
• 76-05-1 trifluoroacetic acid 

Relevant articles and documents

C-MET MODULATORS AND METHODS OF USE

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.