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84923-24-0

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84923-24-0 Usage

Properties

1. Chemical name: 2-Amino-N-(8-(cyclohexylmethyl)-3-beta-nortropanyl)-4-methoxy-5-pyrimidinecarboxamide
2. Also known as: N-Desmethylclozapine
3. Metabolite of Clozapine
4. Less potent than Clozapine
5. Acts as an antagonist at dopamine receptors
6. Similar pharmacological profile to Clozapine
7. Thought to have a role in the therapeutic effects of Clozapine
8. Potential use in improving cognitive function in patients with schizophrenia
9. Studied for potential use in the treatment of inflammatory and autoimmune diseases
10. Modulates the activity of immune cells

Specific content

N-Desmethylclozapine is a metabolite of the antipsychotic medication Clozapine.
It acts as an antagonist at dopamine receptors in the brain.
It has a similar pharmacological profile to Clozapine but is less potent.
Thought to play a role in the therapeutic effects of Clozapine, particularly in improving cognitive function in patients with schizophrenia.
Studied for its potential use in treating inflammatory and autoimmune diseases due to its ability to modulate immune cell activity.

Check Digit Verification of cas no

The CAS Registry Mumber 84923-24-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,9,2 and 3 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84923-24:
(7*8)+(6*4)+(5*9)+(4*2)+(3*3)+(2*2)+(1*4)=150
150 % 10 = 0
So 84923-24-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H31N5O2/c1-27-19-17(11-22-20(21)24-19)18(26)23-14-9-15-7-8-16(10-14)25(15)12-13-5-3-2-4-6-13/h11,13-16H,2-10,12H2,1H3,(H,23,26)(H2,21,22,24)

84923-24-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-N-[8-(cyclohexylmethyl)-8-azabicyclo[3.2.1]octan-3-yl]-4-methoxypyrimidine-5-carboxamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:84923-24-0 SDS

84923-24-0Downstream Products

84923-24-0Relevant articles and documents

Studies on the neuroleptic benzamides. III - Synthesis and antidopaminergic properties of new 3-nortropane derivatives

Dostert,Imbert,Langlois,et al.

, p. 105 - 110 (2007/10/02)

Various benzamides prepared from 4-alkoxy pyrimidine 5-carboxylic acids and 3-amino nortropane derivatives have been tested for their potential antipsychotic activity. Two compounds exhibited pharamacological activity equivalent to that of haloperidol but had lower toxicity and lower potency to induced catalepsy. Antidopaminergic activity is observed mainly in compounds in which the nortropane ring is substituted in the equatorial position, having a benzyl substituent on the basic nitrogen. The influence of electron attractor or donor substituents carried by the benzyl ring has been evaluated. Some aspects of structure-activity relationships are discussed.

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