84923-28-4

Basic information

• Product Name: Acetamide, N-[8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]-, exo-
• CAS NO: 84923-28-4
• Molecular Formula: C16H22N2O
• Molecular Weight: 258.363
• Mol File: 84923-28-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]-, exo-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]-, exo-(84923-28-4)
• EPA Substance Registry System: Acetamide, N-[8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]-, exo-(84923-28-4)

Safety Data

• Hazardous Substances Data: 84923-28-4(Hazardous Substances Data)

Upstream product

• 76272-34-9 8-Benzyl-1αH,5αH-nortropan-3-one Oxime 
• 28957-72-4 N-benzylnortropinone 
• 1515-26-0 (1R,5S)-8-Methyl-8-aza-bicyclo[3.2.1]octan-3-one oxime 
• 532-24-1 tropinone 
• 542-05-2 acetonedicarboxylic acid 
• 76272-36-1 8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl-amine 
• 75-36-5 acetyl chloride 

Downstream Products

• 84923-21-7 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(4-nitro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide 
• 91596-03-1 2-Dimethylamino-4-methoxy-pyrimidine-5-carboxylic acid [(1R,3S,5S)-8-(4-chloro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-amide 
• 84923-17-1 2-amino-4-methoxy-N-<8-(4-fluorobenzyl)azabicyclo<3,2,1>oct-3-β-yl>-5-pyridine carboxamide 
• 84923-24-0 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid ((1R,3S,5S)-8-cyclohexylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide 
• 91596-06-4 N-[(1R,3S,5S)-8-(4-Fluoro-benzyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-acetamide 
• 76272-40-7 8-(4-chlorophenylmethyl)-8-azabicyclo[3.2.1]octane-3β-amine 
• 76352-33-5 3 β-amino-8-(4-fluorophenylmethyl)-8-azabicyclo<3,2,1>octane 
• 76272-53-2 8-(cyclohexylmethyl)-8-azabicyclo[3.2.1]octane-3β-amine 
• 858651-24-8 Acetic acid [1-((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-eth-(Z)-ylidene]-hydrazide 

Relevant articles and documents

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile

This work is a continuation of our previous research, concentrating this time on lead structure modification to increase the 5-HT1A receptor affinity and water solubility of designed compounds. Therefore, the compounds synthesised within the present project included structural analogues of 3β-acylamine derivatives of tropane with the introduction of a methyl substituent in the benzyl ring and a 2-quinoline, 3-quinoline, or 6-quinoline moiety. A series of novel 3β-aminotropane derivatives was evaluated for their affinity for 5-HT1A, 5-HT2A, and D2 receptors, which allowed for the identification of compounds 12e, 12i, and 19a as ligands with highest affinity for the tested receptors; they were then subjected to further evaluation in preliminary in vivo studies. Selected compounds 12i and 19a displayed antipsychotic properties in the d-amphetamine-induced and MK-801-induced hyperlocomotor activity test in mice. Moreover, compound 19a showed significant antidepressant-like activity in the forced swim test in mice.