849235-60-5

Basic information

• Product Name: Benzamide, 4-[[(3,4-dimethoxyphenyl)amino]methyl]-N-[2-nitro-5-(2-thienyl)phenyl]-
• CAS NO: 849235-60-5
• Molecular Formula: C26H23N3O5S
• Molecular Weight: 489.552
• Mol File: 849235-60-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-[[(3,4-dimethoxyphenyl)amino]methyl]-N-[2-nitro-5-(2-thienyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-[[(3,4-dimethoxyphenyl)amino]methyl]-N-[2-nitro-5-(2-thienyl)phenyl]-(849235-60-5)
• EPA Substance Registry System: Benzamide, 4-[[(3,4-dimethoxyphenyl)amino]methyl]-N-[2-nitro-5-(2-thienyl)phenyl]-(849235-60-5)

Safety Data

• Hazardous Substances Data: 849235-60-5(Hazardous Substances Data)

Upstream product

• 849235-53-6 2-nitro-5-thiophen-2-yl-phenylamine 
• 503040-71-9 4-[(3,4-dimethoxy-phenylamino)-methyl]-benzoic acid 

Downstream Products

• 849235-40-1 N-(2-amino-5-butylphenyl)-4-methylbenzamide 
• 849235-39-8 N-(2-amino-5-butylphenyl)-4-{[(3,4-dimethoxyphenyl)amino]methyl}benzamide 

Relevant articles and documents

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity

Significant effort is being made to understand the role of HDAC isotypes in human cancer and to develop antitumor agents with better therapeutic windows. A part of this endeavor was the exploration of the 14 ? internal cavity adjacent to the enzyme catalytic site, which led to the design and synthesis of compound 4 with the unusual bis-(aryl)-type pharmacophore. SAR studies around this lead resulted in optimization to potent, selective, nonhydroxamic acid HDAC inhibitors.