849239-59-4Relevant academic research and scientific papers
The Synthesis and evaluation of a novel class of (E)-3-(1-cyclohexyl-1H- pyrazol-3-yl)-2-methylacrylic acid Hepatitis C virus polymerase NS5B inhibitors
Martin, Scott W.,Glunz, Peter,Beno, Brett R.,Bergstrom, Carl,Romine, Jeffrey L.,Scott Priestley,Newman, Makenzie,Gao, Min,Roberts, Susan,Rigat, Karen,Fridell, Robert,Qiu, Dike,Knobloh, Galina,Wang, Ying-Kai
, p. 2869 - 2872 (2011/06/26)
Herein we report the identification and evaluation of a novel series of (E)-3-(1-cyclohexyl-1H-pyrazol-3-yl)-2-methylacrylic acid derivatives identified from a deannulation study performed on the reported benzimidazole NS5B inhibitor, 1. This resulted in
Cycloalkyl heterocycles for treating Hepatitis C virus
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Page/Page column 30, (2010/02/11)
Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also disclosed.
