6498-34-6

Usage

Uses

Used in Organic Synthesis:
CYCLOHEXYLHYDRAZINE is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, contributing to the formation of a range of organic compounds.
Used in Steam-Generating Systems:
In steam-generating systems, CYCLOHEXYLHYDRAZINE is used as a corrosion inhibitor to prevent the deterioration of system components, thereby extending the operational life and efficiency of the equipment.
Used in Pharmaceutical Production:
CYCLOHEXYLHYDRAZINE is utilized in the production of pharmaceuticals, where it serves as a key intermediate in the synthesis of various medicinal compounds, highlighting its importance in the development of new drugs.
Used in Agrochemical Production:
CYCLOHEXYLHYDRAZINE is also used in the manufacturing of agrochemicals, playing a crucial role in the synthesis of substances that contribute to crop protection and enhancement of agricultural productivity.

InChI:InChI=1/C6H14N2/c7-8-6-4-2-1-3-5-6/h6,8H,1-5,7H2

Upstream product

• 108-85-0 1-bromocyclohexane 
• 20600-69-5 3-cyclohexyl-sydnone 
• 108-94-1 cyclohexanone 
• 108-91-8 cyclohexylamine 
• 3984-18-7 N-(1-cyclohexyl)sulfamide 
• 7647-01-0 hydrogenchloride 
• 2159-74-2 Azocyclohexan 
• 64-17-5 ethanol 
• 7803-57-8 hydrazine hydrate 
• 114035-74-4 cyclohexanone-hydrazone; monohydrate 
• 24214-73-1 cyclohexylhydrazine hydrochloride 
• 91695-93-1 N-Cyclohexyl-hydrazodicarbonsaeure-diethylester 
• 6156-08-7 cyclohexanone hydrazone 
• 98951-35-0 3-cyclohexyl-carbazic acid ethyl ester 

Downstream Products

• 110-82-7 cyclohexane 
• 32137-21-6 cyclohexylhydrazone of cyclohexanone 
• 858838-09-2 2-cyclohexyl-5-methyl-1H-pyrazol-3(2H)-one 
• 41316-46-5 cyclohexyl-hydrazine-N,N'-dicarboxylic acid dianilide 
• 856071-86-8 2-cyclohexyl-4-phenyl semicarbazide 
• 7026-37-1 2-Cyclohexyl-1-phenylcarbamoyl-triazan 
• 21076-42-6 4-tert.Butyl-2-cyclohexyl-thiosemicarbazid 
• 21198-17-4 2-Cyclohexyl-thiosemicarbazid 
• 21076-13-1 2-Cyclohexyl-4-methylthiosemicarbazid 
• 92876-50-1 Thioessigsaeure-(N²-cyclohexyl-hydrazid) 
• 75131-17-8 N-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenyl]-N'-cyclohexyl-hydrazine 
• 38136-10-6 3-(cyclohexylhydrazono-methyl)-rifamycin 
• 25612-00-4 N-Cyclohexyl-hydrazinecarbodithioic acid methyl ester 
• 96534-79-1 Thiobenzoesaeure-(N²-cyclohexyl-hydrazid) 

Relevant academic research and scientific papers

CARBOXAMIDE DERIVATIVES

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Reduction of hydrazines to amines with aqueous solution of titanium(iii) trichloride

N-N bond cleavage in hydrazines is widely used in the preparation of amines and thus occupies a significant place in organic synthesis. In this paper, we report a new method for the reductive cleavage of N-N bonds in hydrazines by commercially available and cheap aqueous titanium(iii) trichloride. The reaction proceeds smoothly under a broad pH range from acidic to neutral and basic conditions to afford amines in good yields. This method is compatible with substrates containing functionalities such as C-C double bonds, benzyl-nitrogen bonds, benzyloxy and acyl groups. The Royal Society of Chemistry 2011.

FUSED HETEROCYCLIC COMPOUNDS

Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Pyrazole urea-based inhibitors of p38 MAP kinase: From lead compound to clinical candidate

We report on a series of N-pyrazole, N′-aryl ureas and their mode of binding to p38 mitogen activated protein kinase. Importantly, a key binding domain that is distinct from the adenosine 5′-triphoshate (ATP) binding site is exposed when the conserved activation loop, consisting in part of Asp168-Phe169-Gly170, adopts a conformation permitting lipophilic and hydrogen bonding interactions between this class of inhibitors and the protein. We describe the correlation of the structure-activity relationships and crystallographic structures of these inhibitors with p38. In addition, we incorporated another binding pharmacophore that forms a hydrogen bond at the ATP binding site. This modification affords significant improvements in binding, cellular, and in vivo potencies resulting in the selection of 45 (BIRB 796) as a clinical candidate for the treatment of inflammatory diseases.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.

Process for producing 3-anilino-5-pyrazolones

A process for producing a 3-anilino-5-pyrazolone which comprises reacting a β-anilino-β-alkoxy-acrylate with a hydrazine in the presence of a compound having a pKa of about 8 up to about 14.