849241-75-4

Upstream product

• 534572-62-8 11β-allyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene 
• 342898-65-1 11α-allyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-ol 
• 89155-71-5 (8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one 
• 147250-16-6 3,17β-dibenzyloxy-11β-(3'-hydroxypropyl)estra-1,3,5(10)-triene 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 849241-78-7 3,17β-dibenzyloxy-11β-(3-(2-fluoroethoxy)propyl)estra-1,3,5(10)-triene 
• 849241-76-5 3,17β-dibenzyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-triene 
• 849241-77-6 3,17β-dibenzyloxy-11β-(3-tert-butoxypropyl)estra-1,3,5(10)-triene 
• 1373112-27-6 3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol 
• 1599458-16-8 C₄₁H₅₆O₃Si 
• 1373112-28-7 3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one 
• 1599458-17-9 C₄₁H₅₄O₃Si 

Relevant academic research and scientific papers

Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities

We have previously found that several families of nonpolar short chain 11β-ethers and esters of estradiol are selective estrogen receptor modulators (SERMs). Surprisingly, the transformation from potent estrogen to anti-estrogen occurs when the 11β-side c

Nonpolar and short side chain groups at C-11β of estradiol result in antiestrogens

We have previously found that esters of 11β-estradiol carboxylates are transformed from an estrogen into an antiestrogen when the 11β-side chain is increased in length from four to five non-hydrogen atoms (n ≥ 5). To understand the structural requirements

11beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer

The present invention relates to novel 11-β estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.