534572-62-8Relevant academic research and scientific papers
Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities
Zhang, Jing-Xin,Labaree, David C.,Hochberg, Richard B.
, p. 567 - 570 (2014/05/06)
We have previously found that several families of nonpolar short chain 11β-ethers and esters of estradiol are selective estrogen receptor modulators (SERMs). Surprisingly, the transformation from potent estrogen to anti-estrogen occurs when the 11β-side c
Synthesis of 11β-perfluorohexylestradiol
Agouridas, Vangelis,Blazejewski, Jean-Claude,Magnier, Emmanuel,Popkin, Matthew E.
, p. 8907 - 8912 (2007/10/03)
We report the synthesis of 11β-perfluorohexylestradiol 1e using a perfluoroorganometallic reagent for the introduction of the fluorous part. This compound is useful for biological studies and for imaging the ERa estradiol receptor distribution in the whol
11beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer
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Page/Page column 6, (2010/02/07)
The present invention relates to novel 11-β estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.
Synthesis and evaluation of B-, C-, and D-ring-substituted estradiol carboxylic acid esters as locally active estrogens
Labaree, David C.,Zhang, Jing-Xin,Harris, Heather A.,O'Connor, Craig,Reynolds, Toni Y.,Hochberg, Richard B.
, p. 1886 - 1904 (2007/10/03)
We have synthesized derivatives of estradiol that are structurally modified to serve as "soft" estrogens and act within a geographically limited area of the body; estrogens without systemic action. We have previously shown with 16α-substituted analogues o
