849359-76-8Relevant academic research and scientific papers
The PdCl2-catalyzed sequential heterocyclization/Michael addition cascade in the synthesis of 2,3-disubstituted indoles
Janreddy, Donala,Kavala, Veerababurao,Kuo, Chun-Wei,Kuo, Ting-Shen,He, Chiu-Hui,Yao, Ching-Fa
supporting information, p. 3323 - 3330 (2013/04/23)
A cascade reaction of 2-N-unprotected-2-alkynylanilines and various electron-deficient alkenes in the presence of PdCl2 provided 2,3-disubstituted indole derivatives, whereas, in the presence of Pd(OAc) 2, the same reaction resulted in the production of N-alkylated-2-alkynylaniline derivatives.
Gold-catalyzed synthesis of 2-substituted, 2,3-disubstituted and 1,2,3-trisubstituted indoles in [bmim]BF4
Ambrogio, Ilaria,Arcadi, Antonio,Cacchi, Sandro,Fabrizi, Giancarlo,Marinelli, Fabio
, p. 1775 - 1779 (2008/01/01)
Cyclization of 2-alkynylanilines in the presence of NaAuCl 4·H2O using [bmim]BF4 as the reaction medium afforded 2-substituted indoles in high yields. The catalyst system was best recycled using n-Bu4NAuCl4. 2,3-Disubstituted indoles could be prepared from 2-alkynylanilines and 3-buten-2-one through a one-flask annulation-alkylation sequence and 1,2,3-trisubstituted indoles were obtained from the same starting materials via an aza-Michael addition-annulation- alkylation process. Georg Thieme Verlag Stuttgart.
