84939-40-2

Upstream product

• 104-94-9 4-methoxy-aniline 
• 7205-91-6 phenylthiomethyl chloride 
• 84939-22-0 (2R,3R)-3-Methyl-oxirane-2-carboxylic acid benzenesulfonylmethyl-(4-methoxy-phenyl)-amide 
• 84939-44-6 (3S,4R)-4-Benzenesulfinyl-3-((R)-1-hydroxy-ethyl)-1-(4-methoxy-phenyl)-azetidin-2-one 
• 84939-27-5 (2R,3R)-3-Methyl-oxirane-2-carboxylic acid benzenesulfinylmethyl-(4-methoxy-phenyl)-amide 
• 84939-23-1 (2R,3R)-3-Methyl-oxirane-2-carboxylic acid (4-methoxy-phenyl)-phenylsulfanylmethyl-amide 
• 84939-28-6 (2S,3R)-2-Bromo-3-hydroxy-N-(4-methoxy-phenyl)-butyramide 
• 84939-32-2 2R,3R-2,3-epoxybutyric acid-p-methoxyphenylamide 
• 84986-63-0 (3S,4R)-3-((R)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-phenylsulfanyl-azetidin-2-one 

Downstream Products

• 84939-50-4 3S-<1R-(methoxymethoxy)-ethyl>-4R-(phenylsulfonyl)-azetidin-2-one 

Relevant academic research and scientific papers

Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor

Improved processes for preparation of racemic, cis- and optically active (3S,4R)-3[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones, process improvements for certain intermediates therefor and a novel intermediate for said racemic, cis- and trans-compounds, which compounds are useful as intermediates for antibacterial 5R,6S-6-[1(R)-hydroxyethyl]-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids and the pharmaceutically-acceptable salts and the pivaloyloxymethyl esters thereof.

SYNTHESIS OF OPTICALLY ACTIVE AZETIDIN-2-ONES FROM L-THREONINE

3S-(1R-Hydroxyethyl)-4R-phenylsulfonylazetidin-2-one derivative was synthesized from L-threonine in an 8-step process including the novel transformation of the oxirane ring to the azetidin-2-one.