84939-32-2

Upstream product

• 86561-72-0 (2R,3R)-2,3-epoxybutanoic acid 
• 104-94-9 4-methoxy-aniline 
• 84939-28-6 (2S,3R)-2-Bromo-3-hydroxy-N-(4-methoxy-phenyl)-butyramide 

Downstream Products

• 94944-07-7 (3S,4S,1'R) N-p-methoxyphenyl-3-(1'-hydroxyethyl)-4-benzoylazetidin-2-one 
• 84939-40-2 1-N-(p-Methoxyphenyl)-(3S,4R)-3-[1(R)-hydroxyethyl]-4-phenylsulfonylazetidin-2-one 
• 84939-36-6 (3S,4S)-3-((R)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-phenylsulfanyl-azetidin-2-one 
• 84986-63-0 (3S,4R)-3-((R)-1-Hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-phenylsulfanyl-azetidin-2-one 
• 84939-45-7 (3S,4R)-4-Benzenesulfonyl-3-((R)-1-methoxymethoxy-ethyl)-1-(4-methoxy-phenyl)-azetidin-2-one 
• 84939-22-0 (2R,3R)-3-Methyl-oxirane-2-carboxylic acid benzenesulfonylmethyl-(4-methoxy-phenyl)-amide 
• 84939-27-5 (2R,3R)-3-Methyl-oxirane-2-carboxylic acid benzenesulfinylmethyl-(4-methoxy-phenyl)-amide 
• 84939-44-6 (3S,4R)-4-Benzenesulfinyl-3-((R)-1-hydroxy-ethyl)-1-(4-methoxy-phenyl)-azetidin-2-one 
• 84939-23-1 (2R,3R)-3-Methyl-oxirane-2-carboxylic acid (4-methoxy-phenyl)-phenylsulfanylmethyl-amide 

Relevant academic research and scientific papers

Novel azetidinones for carbapenems and fragmentation in the allylamine precursor analogue

(2R,3R)-N-(3-Methoxy-2,3-dioxopropyl)-N-(4-methoxy-phenyl)-2,3-epoxybutanamide on treatment with strong bases (LDA, LHMDS) gives 3-[(1R)-1-hydroxyethyl]azetidin-2-one derivative, while the N-(3-methoxy-2-methylidene-3-oxo-propyl) analogue undergoes fragme

SYNTHESIS OF OPTICALLY ACTIVE AZETIDIN-2-ONES FROM L-THREONINE

3S-(1R-Hydroxyethyl)-4R-phenylsulfonylazetidin-2-one derivative was synthesized from L-threonine in an 8-step process including the novel transformation of the oxirane ring to the azetidin-2-one.