84939-74-2Relevant academic research and scientific papers
ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
Wilde, Richard G.,Billheimer, Jeffrey T.,Germain, Sandie J.,Hausner, Elizabeth A.,Meunier, Paul C.,Munzer, Deborah A.,Stoltenborg, Janet K.,Gillies, Peter J.,Burcham, Deborah L.,Huang, Shiew-Mai,Klaczkiewicz, John D.,Ko, Soo S.,Wexler, Ruth R.
, p. 1493 - 1513 (2007/10/03)
Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesteror esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds.
Synthesis of pyrazolo[3,4-e][1,4]diazepine-4,7-diones with central nervous system activity
Sprio,Caronna,Migliara,Petruso,Matera
, p. 809 - 818 (2007/10/02)
The synthesis of 1-phenyl-5,8-dimethyl-1,4,5,6,7,8-hexahydro-pyrazolo[3,4-e][1,4] diazepin-4,7-dione and of 1-phenyl-3,5,8-trimethyl-1,4,5,6,7,8-hexahydro-pyrazolo[3,4-e] [1,4]diazepin-4,7-dione is described. These compounds exhibit activity on CNS in animals.
Synthesis and Pharmacological Activities of 5-(Aminoacetylamino)-4-carbethoxy-1-phenylpyrazoles
Pathak, U. S.,Devani, M. B.,Shishoo, C. J.,Patel, H. H.,Gandhi, T. P.,Patel, R. B.
, p. 602 - 604 (2007/10/02)
A number of new 5-(aminoacetylamino)-4-carbethoxy-1-phenyl-pyrazoles have been prepared and screened for their pharmacological activities.Some of these compounds exhibit significant analgesic and antiinflammatory activities.
