849407-79-0Relevant academic research and scientific papers
Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics
Liang, Chang-Hsing,Yao, Sulan,Chiu, Yu-Hung,Leung, Po Yee,Robert, Nicole,Seddon, Jaime,Sears, Pam,Hwang, Chan-Kou,Ichikawa, Yoshi,Romero, Alex
, p. 1307 - 1310 (2007/10/03)
A series of new triazole-containing ketolides and 2-fluoro-ketolides in which the 5-O-desosamine was replaced by unnatural sugars were synthesized and evaluated against relevant macrolide-sensitive and macrolide-resistant respiratory pathogens. Excellent
An efficient entry to new sugar modified ketolide antibiotics
Romero, Alex,Liang, Chang-Hsing,Chiu, Yu-Hung,Yao, Sulan,Duffield, Jonathan,Sucheck, Steven J.,Marby, Ken,Rabuka, David,Leung, Po Yee,Shue, Youe-Kong,Ichikawa, Yoshi,Hwang, Chan-Kou
, p. 1483 - 1487 (2007/10/03)
A new and efficient route to a ketolide aglycon served as a basis for the unprecedented 5-O-glyco-modification of ketolide antibiotics. Combined with an effective copper-catalyzed triazole-forming reaction a series of novel and potent ketolide antibiotics
