84941-21-9Relevant academic research and scientific papers
REACTION OF 3,4-DICYANO-5-AMINOPYRAZOLE WITH ETHYL ORTHOFORMATEI730
Bulychev, Yu.N.,Korbukh, I.A.,Preobrazhenskaya, M.N.
, p. 1302 - 1305 (2007/10/02)
The condensation of 3,4-dicyano-5-aminopyrazole with ethyl orthoformate was studied.Under severe conditions (150 deg C) the principal reaction product is N-ethyl-3,4-dicyano-5-ethoxymethylaminopyrazole.Alkylation of the pyrazole ring does not occur at 100 deg C, but 3,4-dicyano-5-ethoxymethyleneaminopyrazole is formed.Isomeric 1-and 2-ethyl-4-aminopyrazolopyrimidine-3-carboxylic acid methyl imino esters were obtained by the action of a methanol solution of ammonia on the principal reaction product.This constitutes evidence that N-ethyl-3,4-dicyano-5-ethoxymethyleneaminopyrazole is a mixture of 1- and 2-ethyl- 3,4-dicyano-5-ethoxymethyleneaminopyrazoles.
