84944-23-0Relevant academic research and scientific papers
Preparation method of lodoxamide tromethamine impurity
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Paragraph 0036-0055, (2021/06/21)
The invention relates to the technical field of preparation of pharmaceutical compound impurities, and concretely relates to a preparation method of a lodoxamide tromethamine impurity. The preparation method comprises the following steps: condensing 3, 5-diamino-4-chlorobenzonitrile serving as a raw material and oxalyl chloride, and cracking under the catalysis of acid to obtain the target impurity. The method provided by the invention has the advantages of easily available raw materials, simple and stable operation and mild reaction conditions, the purity of the obtained impurity can reach 95% or above, and the quality control requirements of lodoxamide tromethamine raw materials and preparations can be met.
