849455-40-9

Upstream product

• 123-54-6 acetylacetone 
• 1694-29-7 3-chloropentane-2,4-dione 
• 154371-25-2 1-(3-chloro-4-fluorophenyl)thiourea 

Downstream Products

• 1257438-85-9 1-[2-(3-chloro-4-fluorophenylamino)-4-methyl-thiazole-5-yl]-3-(3,4,5-trimethoxyphenyl)-propen-1-one 
• 1333391-37-9 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine 
• 1333391-38-0 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-m-tolylamine 
• 1333391-40-4 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-o-tolylamine 
• 1333391-59-5 3-dimethylamino-1-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone 

Relevant academic research and scientific papers

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright

Synthesis and anticancer evaluation of thiazolyl-chalcones

Thirty-seven (E)-1-(4-methyl-2-arylaminothiazol-5-yl)-3-arylprop-2-en-1- ones were synthesized via Claisen-Schmidt condensation of 1-(4-methyl-2- (arylamino)thiazol-5-yl)ethanone with the corresponding arylaldehydes. All these thiazolyl-chalcones were cha