154371-25-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA is used as a potential therapeutic agent for cancer treatment due to its antiproliferative and cytotoxic effects on cancer cells. It targets the inhibition of cell proliferation and induction of cell death in various types of cancer, making it a promising candidate for further research and development in oncology.
Used in Autoimmune and Inflammatory Disease Treatment:
1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA is also used as a potential treatment for autoimmune diseases and inflammatory conditions. Its effects on modulating the immune system and reducing inflammation are being studied, which could lead to new therapeutic approaches for these conditions.

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 17356-08-0 thiourea 
• 1147550-11-5 ammonium thiocyanate 
• 431075-50-2 N-(3-chloro-5-fluorophenyl)-N'-benzoylthiourea 

Downstream Products

• 154371-22-9 2-(3-Chloro-4-fluoro-phenylamino)-1-thia-3,9,10-triaza-anthracen-4-one 
• 101337-92-2 2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole 
• 1013479-56-5 ethyl 1-(3-chloro-4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-4-(3-nitrophenyl)-2-thioxopyrimidine-5-carboxylate 
• 1013612-99-1 ethyl 1-(3-chloro-4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-4-(2-nitrophenyl)-2-thioxopyrimidine-5-carboxylate 
• 849455-40-9 C₁₂H₁₀ClFN₂OS 
• 1198108-43-8 2-(3-chloro-4-fluorophenylamino)-4-(4-bromophenyl)thiazole 
• 1239982-52-5 2-(3-chloro-4-fluorophenylamino)-4-(4-chlorophenyl)thiazole 
• 1266927-15-4 C₁₀H₇Cl₂FN₂S 
• 729581-03-7 C₁₈H₁₄ClFN₂O₂S 
• 956473-15-7 C₁₈H₁₃Cl₂FN₂O₂S 
• 1038891-06-3 1-(3-chloro-4-fluorophenyl)-4,5-diphenyl-1,3-dihydroimidazole-2-thione 
• 1024590-18-8 C₂₄H₁₇ClFN₃O₂S 

Relevant academic research and scientific papers

Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

Synthesis and antitumor evaluation of 5-(benzo[: D] [1,3]dioxol-5-ylmethyl)-4-(tert -butyl)- N -arylthiazol-2-amines

A series of novel N-aryl-5-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(tert-butyl)thiazol-2-amines (C1-C31) were synthesized and evaluated for their antitumor activities against HeLa, A549 and MCF-7 cell lines. Some tested compounds showed potent growth inhibition properties with IC50 values generally below 5 μM against the three human cancer cells lines. Compound C27 showed potent activities against HeLa and A549 cell lines with IC50 values of 2.07 ± 0.88 μM and 3.52 ± 0.49 μM, respectively. Compound C7 (IC50 = 2.06 ± 0.09 μM) was the most active compound against A549 cell line, while compound C16 (IC50 = 2.55 ± 0.34 μM) showed the best inhibitory activity against the MCF-7 cell line. The preliminary mechanism of the inhibitory effect was investigated via further experiments, such as morphological analysis by dual AO/EB staining and Hoechst 33342 staining, and cell apoptosis and cycle assessment by FACS analysis. The results illustrated that compound C27 could induce apoptosis and cause both S-phase and G2/M-phase arrests in HeLa cell line. Therefore, compound C27 could be developed as a potential antitumor agent.

Synthesis and Cytotoxicity in Vitro of N-Aryl-4-(Tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine

A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines were synthesized in a green way. H2O2-NaBr Brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. All of the target compounds were confirmed by1H NMR and elemental analysis and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound 2i was the most potent compound with the IC50 values of 9 μMagainst Hela cells and 15 μMagainst Bel-7402 cells, respectively.

Synthesis of some new dihydropyrimidines by iodine as a catalyst at ambient temperature and evaluation of their biological activity

An improved method for the synthesis of some new dihydropyrimidines from aromatic aldehydes, 1,3-dicarbonyl compounds, and thiourea with significant enhancement in reaction rates, short reaction time (4-6 h), good to excellent yields (70-93%), and ambient temperature using molecular iodine as catalyst is described. The biological evaluation revealed that the newly synthesized compounds 4a-j and 7a-j exhibited good antimicrobial activity and moderate antimycobacterial activity against Mycobacterium tuberculosis H37RV.

Synthesis and in vivo diuretic activity of biphenyl benzothiazole-2- carboxamide derivatives

A series of N-{(substituted)1,3-benzothiazol-2-yl}-1,1'-biphenyl-4- carboxamides was synthesized by reaction between biphenyl acid chloride and 2-aminobenzothiazole. The synthesized compounds were screened in vivo for diuretic activity. Among the series, N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4- carboxamide (II) was found to be the most promising candidate.

Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents

A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen.