84952-45-4

Upstream product

• 95244-36-3 N-<(1,1-dimethylethoxy)carbonyl>-S-<(4-methylphenyl)methyl>-L-cysteinamide 
• 61925-77-7 Boc-cysteine(4-Me-Bn) 

Downstream Products

• 115370-32-6 Thioacetic acid S-{(R)-2-[(R)-1-carbamoyl-2-(4-methyl-benzylsulfanyl)-ethylcarbamoyl]-3-phenyl-propyl} ester 
• 115370-33-7 Thioacetic acid S-{(S)-2-[(R)-1-carbamoyl-2-(4-methyl-benzylsulfanyl)-ethylcarbamoyl]-3-phenyl-propyl} ester 

Relevant academic research and scientific papers

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.