95244-36-3

Upstream product

• 61925-77-7 Boc-cysteine(4-Me-Bn) 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 115370-33-7 Thioacetic acid S-{(S)-2-[(R)-1-carbamoyl-2-(4-methyl-benzylsulfanyl)-ethylcarbamoyl]-3-phenyl-propyl} ester 
• 115370-32-6 Thioacetic acid S-{(R)-2-[(R)-1-carbamoyl-2-(4-methyl-benzylsulfanyl)-ethylcarbamoyl]-3-phenyl-propyl} ester 
• 84952-45-4 S-<(4-methylphenyl)methyl>-L-cysteinamide 

Relevant academic research and scientific papers

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.

Mercapto-acylamino acid antihypertensives

Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.