849669-16-5Relevant academic research and scientific papers
DESYMMETRISATION PROCESS
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Page/Page column 24-25, (2008/06/13)
Provided is a process for producing a P-chiral phosphine compound using a cross-metathesis coupling reaction between a non-chiral phosphine and an olefin or an alkyne. The P-chiral phosphine compounds produced by this process are also disclosed.
Desymmetrization by direct cross-metathesis producing hitherto unreachable P-stereogenic phosphine oxides
Bisaro, Fabrice,Gouverneur, Véronique
, p. 2395 - 2400 (2007/10/03)
Desymmetrization of prochiral di- and trialkenyl phosphine oxides by cross-metathesis with various olefinic partners allowed direct access to novel racemic P-stereogenic products featuring two or three different alkenyl groups. The excellent control of product selectivity and E/Z selectivity allowed the preparation of desymmetrized products in good yields from readily available precursors. These are the first examples of desymmetrization of prochiral substrates by direct cross-metathesis.
