849694-25-3

Usage

Chemical class

Indole derivatives

Structural features

+ Indole ring
+ Aminoethoxy group substitution at position 5
+ Phenylsulfonyl group substitution at position 1

Potential applications

Pharmaceutical, medicinal chemistry

Uses

+ Building block or starting material for synthesis of new drug candidates
+ Valuable tool for the development of novel chemical entities with diverse biological activities

Importance

Further research and exploration of its properties could lead to the discovery of new therapeutic agents.

Upstream product

• 1022955-33-4 1-[5-hydroxy-1-(phenylsulfonyl)-1H-indol-4-yl]ethanone 
• 849694-28-6 1-benzenesulfonyl-5-(2-chloro-ethoxy)-1H-indole 
• 849694-27-5 5-(2-chloroethoxy)-1H-indole 
• 1953-54-4 indol-5-ol 
• 849694-29-7 5-(2-azido-ethoxy)-1-benzenesulfonyl-1H-indole 

Downstream Products

• 1022956-62-2 10-chloro-1-methyl-8-(phenylsulfonyl)-3,8-dihydro-4H-[1,4]oxazepino[6,7-e]indole 
• 1022956-54-2 N-(2-{[3-chloro-1-(phenylsulfonyl)-1H-indol-5-yl]oxy}ethyl)acetamide 
• 1022956-46-2 1-isopropyl-2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole 
• 1022956-43-9 1-isopropyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole 
• 1022956-39-3 1-isopropyl-8-(phenylsulfonyl)-3,8-dihydro-4H-[1,4]oxazepino[6,7-e]indole 
• 1022955-45-8 (1S)-1-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole 
• 1022955-48-1 (1R)-1-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole 
• 1022955-41-4 1-methyl-8-(phenylsulfonyl)-3,8-dihydro-4H-[1,4]oxazepino[6,7-e]indole 
• 1022956-35-9 2-methyl-N-(2-{[1-(phenylsulfonyl)-1H-indol-5-yl]oxy}ethyl)propanamide 
• 1022955-54-9 N-(2-{[1-(phenylsulfonyl)-1H-indol-5-yl]oxy}ethyl)acetamide 

Relevant academic research and scientific papers

8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS

The present invention relates to compounds of the formula (I) wherein A, X and R1 to R9 are as described herein; to pharmaceutical compositions comprising the said compounds; to processes for their preparation; and to the use of the compounds as medicaments against 5-HT6 receptor-related disorders.

4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands

The preparation of a novel class of 4-(2-aminoethoxy)-N-(phenylsulfonyl) indoles which exhibit high affinity towards the 5-HT6 receptor is reported here. Among these compounds, 4-(2-methylaminoethoxy)-N-(phenylsulfonyl) indole 5g showed superior affinity (Ki = 1 nM) towards the 5-HT 6 receptor as well as excellent selectivity (>2000-fold) against the closely related subtype 5-HT7 receptor.