849694-29-7Relevant academic research and scientific papers
4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands
Zhou, Ping,Yan, Yinfa,Bernotas, Ronald,Harrison, Boyd L.,Huryn, Donna,Robichaud, Albert J.,Zhang, Guo Ming,Smith, Deborah L.,Schechter, Lee E.
, p. 1393 - 1396 (2007/10/03)
The preparation of a novel class of 4-(2-aminoethoxy)-N-(phenylsulfonyl) indoles which exhibit high affinity towards the 5-HT6 receptor is reported here. Among these compounds, 4-(2-methylaminoethoxy)-N-(phenylsulfonyl) indole 5g showed superior affinity (Ki = 1 nM) towards the 5-HT 6 receptor as well as excellent selectivity (>2000-fold) against the closely related subtype 5-HT7 receptor.
