849706-05-4

Basic information

• Product Name: N-[[(3R,4S)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam
• Synonyms: N-[[(3R,4S)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam
• CAS NO: 849706-05-4
• Molecular Weight: 508.682
• Mol File: 849706-05-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[[(3R,4S)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam(CAS DataBase Reference)
• NIST Chemistry Reference: N-[[(3R,4S)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam(849706-05-4)
• EPA Substance Registry System: N-[[(3R,4S)-4-benzyloxy-1-(benzyl)pyrrolidin-3-yl]carbonyl]-(2'S)-bornane-10,2-sultam(849706-05-4)

Safety Data

• Hazardous Substances Data: 849706-05-4(Hazardous Substances Data)

Upstream product

• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 320385-10-2 (E)-3-benzyloxypropenoyl-(2'S)-bornane-10,2-sultam 
• 35963-20-3 (R)-10-camphorsulfonic acid 
• 154581-21-2 (E)-3-benzyloxypropenoyl chloride 
• 127762-22-5 (E)-3-(benzyloxy)acrylic acid 
• 108448-77-7 (+)-camphorsultam 
• 53215-95-5 N-(trimethylsilylmethyl)benzylamine 
• 100-46-9 benzylamine 
• 107869-45-4 (+)-(camphorylsulfonyl)imine 
• 72597-34-3 (+/-)-10-Camphorsulfonamide 
• 21286-54-4 D-camphor-10-sulfonyl chloride 

Relevant articles and documents

Process for the preparation of substituted pyrrolidine derivatives and intermediates

Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.