849737-91-3Relevant academic research and scientific papers
Development of a Synthetic Receptor for the Food Toxin Beauvericin: A Tale of Carbazole and Steroids
Ornelis, Vincent,Rajkovic, Andreja,Sas, Benedikt,De Saeger, Sarah,Madder, Annemieke
, p. 6368 - 6371 (2018)
The synthesis of the first synthetic receptor showing high affinity for the toxic ionophoric cyclodepsipeptide beauvericin is described. Binding results in a pronounced increase in fluorescence intensity of the receptor, while this increase is not observed for a very similar ionophore such as valinomycin. Experiments that shed light on the nature of this selectivity are discussed.
SYNTHETIC RECEPTORS FOR IONOPHORIC COMPOUNDS
-
Page/Page column 24; 26, (2019/09/18)
The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection,
NEW PHOSPHORAMIDITE COMPOUNDS
-
Page 8; 17, (2010/02/07)
Novel phosphoramidites having various functional groups can be advantageously used as new building blocks to synthesize various oligodeoxyribonucleotides which are useful for the development of a highly efficient diagnostic agent and the synthesis of new
Structure-Activity Relationships of Cytotoxic Cholesterol-Modified DNA Duplexes
Reed, Michael W.,Lukhtanov, Eugeny A.,Gorn, Vladimir V.,Lucas, Deborah D.,Zhou, James H.,et al.
, p. 4587 - 4596 (2007/10/03)
Short DNA duplexes with cholesterol linked at the 3'-terminus of each strand have unique, selective cytotoxic properties.The structural requirements for biological activity were explored through chemical synthesis of analogs and testing in cultured hepatoma cells.Effects of modifications to the sequence, backbone, 3'-sterol, 3;-linker, and 5'-terminus were evaluated.Self-complementary 3'-modified oligodeoxynucleotide (ODN) 10-mers were prepared from solid supports bearing the modification and linker of interest.Any changes to the normal phosphodiester backbone were poorly tolerated.The presence of cholesterol or a closely related sterol was an absolute requirement for activity.The length and position of attachment of the linker to cholesterol was important, with longer linkers showing reduced activity.Large, lipophilic groups at the 5'terminus gave reduced cytotoxicity and poor solubility properties.The short length and unique structure of these ODNs allowed efficient automated synthesis on a 400 μmol scale and simplified purification.
