849771-01-3

Upstream product

• 849770-98-5 2-amino-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionic acid ethyl ester 
• 849770-95-2 [5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxymethoxy-2-methyl-pyridin-4-ylmethyl]-carbamic acid tert-butyl ester 
• 849770-94-1 [5-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-2-methyl-pyridin-4-ylmethyl]-carbamic acid tert-butyl ester 
• 849770-97-4 methanesulfonic acid 4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethyl ester 
• 849770-96-3 (5-hydroxymethyl-3-methoxymethoxy-2-methyl-pyridin-4-ylmethyl)-carbamic acid tert-butyl ester 
• 210034-86-9 (3-hydroxy-5-hydroxymethyl-2-methylpyridin-4-ylmethyl)carbamic acid tert-butyl ester 
• 85-87-0 pyridoxamine 
• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10065-72-2 L-Alanine methyl ester 
• 849771-00-2 (R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionic acid 

Downstream Products

• 849771-02-4 (S)-2-[(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-(4-aminomethyl-5-hydroxy-6-methyl-pyridin-3-ylmethylsulfanyl)-propionylamino]-propionic acid methyl ester 

Relevant academic research and scientific papers

Chiral polyamines from reduction of polypeptides: Asymmetric pyridoxamine-mediated transaminations

BH3·THF can reduce polypeptides to polyamines with retention of chirality. The resulting polyamines are intriguing general platforms for asymmetric catalysis, given the diverse structures available and their relative ease of synthesis. We have constructed a number of chiral pyridoxamine catalysts based on reduced peptides. These compounds transaminate α-ketoacids with moderate to good enantioselectivity, while their peptidyl counterparts show almost no chiral induction.